IL27RA Antibody (PACO16538)
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주문- SKU:
- PACO16538
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL27RA Antibody (PACO16538) |
Antibody SKU: | PACO16538 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human IL27RA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16538(IL27RA Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane: Jurkat cells, Primary antibody: PACO16538(IL27RA Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16538(IL27RA Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid, level, and is predicted to be a glycosylated transmembrane protein. |
Synonyms: | interleukin 27 receptor, alpha |
UniProt Protein Function: | IL27RA: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; immune response |
NCBI Summary: | In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q6UWB1 |
NCBI GenInfo Identifier: | 116242518 |
NCBI Gene ID: | 9466 |
NCBI Accession: | Q6UWB1.2 |
UniProt Secondary Accession: | Q6UWB1,O60624, A0N0L1, |
UniProt Related Accession: | Q6UWB1 |
Molecular Weight: | 69,474 Da |
NCBI Full Name: | Interleukin-27 receptor subunit alpha |
NCBI Synonym Full Names: | interleukin 27 receptor subunit alpha |
NCBI Official Symbol: | IL27RA |
NCBI Official Synonym Symbols: | CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1 |
NCBI Protein Information: | interleukin-27 receptor subunit alpha |
UniProt Protein Name: | Interleukin-27 receptor subunit alpha |
UniProt Synonym Protein Names: | Cytokine receptor WSX-1; Cytokine receptor-like 1; Type I T-cell cytokine receptor; TCCR; ZcytoR1 |
Protein Family: | Interleukin-27 receptor |
UniProt Gene Name: | IL27RA |
UniProt Entry Name: | I27RA_HUMAN |
Antibodies |
Anti-IL27RA Antibody (CAB8176) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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