IL18BP Antibody (PACO33740)
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주문- SKU:
- PACO33740
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL18BP Antibody (PACO33740) |
Antibody SKU: | PACO33740 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Interleukin-18-binding protein (31-183AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO33740 at dilution of 1:100. |
Background: | Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. |
Synonyms: | Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa), IL18BP |
UniProt Protein Function: | IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; extracellular region Molecular Function:receptor antagonist activity; interleukin-18 binding Biological Process: T-helper 1 type immune response; response to lipopolysaccharide |
NCBI Summary: | The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
UniProt Code: | O95998 |
NCBI GenInfo Identifier: | 251757286 |
NCBI Gene ID: | 10068 |
NCBI Accession: | O95998.2 |
UniProt Secondary Accession: | O95998,O95993, O96027, Q9NZA9, Q9UBR7, B3KUZ0, B7WPK4 |
UniProt Related Accession: | O95998 |
Molecular Weight: | 17,478 Da |
NCBI Full Name: | Interleukin-18-binding protein |
NCBI Synonym Full Names: | interleukin 18 binding protein |
NCBI Official Symbol: | IL18BP |
NCBI Official Synonym Symbols: | IL18BPa |
NCBI Protein Information: | interleukin-18-binding protein; IL-18BP; MC51L-53L-54L homolog gene product; tadekinig-alfa |
UniProt Protein Name: | Interleukin-18-binding protein |
UniProt Synonym Protein Names: | Tadekinig-alfa |
Protein Family: | Interleukin-18-binding protein |
UniProt Gene Name: | IL18BP |
UniProt Entry Name: | I18BP_HUMAN |
Antibodies |
Anti-IL-18BP Antibody (CAB6445) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |