IL17RA Antibody (PACO22054)
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주문- SKU:
- PACO22054
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL17RA Antibody (PACO22054) |
Antibody SKU: | PACO22054 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human IL17RA. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from LOVO cells, using IL17RAantibody. |
Background: | Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. |
Synonyms: | IL-17 receptor; IL-17RA; IL17RA; interleukin-17 receptor; |
UniProt Protein Function: | Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). |
NCBI Summary: | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q96F46 |
NCBI GenInfo Identifier: | 116242517 |
NCBI Gene ID: | 23765 |
NCBI Accession: | Q96F46.2 |
UniProt Secondary Accession: | Q96F46,O43844, Q20WK1, |
UniProt Related Accession: | Q96F46 |
Molecular Weight: | 92,153 Da |
NCBI Full Name: | Interleukin-17 receptor A |
NCBI Synonym Full Names: | interleukin 17 receptor A |
NCBI Official Symbol: | IL17RA |
NCBI Official Synonym Symbols: | CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R |
NCBI Protein Information: | interleukin-17 receptor A |
UniProt Protein Name: | Interleukin-17 receptor A |
UniProt Synonym Protein Names: | CDw217; CD_antigen: CD217 |
Protein Family: | Interleukin-17 receptor |
UniProt Gene Name: | IL17RA |
Antibodies | ELISA Kits |
Anti-IL-17RA Antibody (CAB10052) | Human IL-17RA (Interleukin 17 receptor A) ELISA Kit (HUFI04701) |
Anti-IL-17A Receptor Antibody (CAB5163) | |
IL17RA Antibody (PACO03738) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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