IL13 Antibody (PACO21243)
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주문- SKU:
- PACO21243
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL13 Antibody (PACO21243) |
Antibody SKU: | PACO21243 |
Size: | 100ul(100ug) |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant protein of human IL13 |
Form: | Liquid |
Storage Buffer: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts of recombinant rotein using IL13 antibody. |
Background: | IL-13 is produced by T cells and is important in the TH2 response. IL-13 targets include B cells, eosinophils, fibroblasts, mast cells and macrophages. IL-13 binds specifically to IL-13R α 1 that complexes with IL-4R α to form the Type II IL-4R. Jak1 and Tyk2 are activated and signal through Stat3 and Stat6. IL-13R α 2 is a different gene product, lacks the intracellular domain, does not complex with IL-4R α and does not signal. The extracellular domain of IL-13R α 2 is often elevated in diseased states. IL-13 plays key roles in airway hyperresponsiveness (AHR) of allergic asthma and modulates resistance to parasitic organisms. |
Synonyms: | IL13; ALRH; BHR1; IL-13; MGC116786; MGC116788; MGC116789; P600 |
UniProt Protein Function: | IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5q31 Cellular Component: extracellular region; extracellular space Molecular Function:interleukin-13 receptor binding; protein binding Biological Process: cell motility; cell-cell signaling; positive regulation of B cell proliferation; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation Disease: Allergic Rhinitis; Asthma, Susceptibility To |
NCBI Summary: | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35225 |
NCBI GenInfo Identifier: | 239938644 |
NCBI Gene ID: | 3596 |
NCBI Accession: | P35225.2 |
UniProt Secondary Accession: | P35225,O43644, Q4VB52, Q9UDC7, |
UniProt Related Accession: | P35225 |
Molecular Weight: | 15,816 Da |
NCBI Full Name: | Interleukin-13 |
NCBI Synonym Full Names: | interleukin 13 |
NCBI Official Symbol: | IL13 |
NCBI Official Synonym Symbols: | P600; IL-13 |
NCBI Protein Information: | interleukin-13 |
UniProt Protein Name: | Interleukin-13 |
Protein Family: | Interleukin |
UniProt Gene Name: | IL13 |
UniProt Entry Name: | IL13_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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