IL11RA Antibody (PACO13969)
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주문- SKU:
- PACO13969
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL11RA Antibody (PACO13969) |
Antibody SKU: | PACO13969 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human IL11RA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO13969(IL11RA Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. |
Synonyms: | Interleukin-11 receptor subunit alpha |
UniProt Protein Function: | IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13 Cellular Component: integral to plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction; developmental process; embryo implantation Disease: Craniosynostosis And Dental Anomalies |
NCBI Summary: | Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012] |
UniProt Code: | Q14626 |
NCBI GenInfo Identifier: | 55976300 |
NCBI Gene ID: | 3590 |
NCBI Accession: | Q14626.2 |
UniProt Secondary Accession: | Q14626,Q16542, Q5VZ80, Q7KYJ7, |
UniProt Related Accession: | Q14626 |
Molecular Weight: | 422 |
NCBI Full Name: | Interleukin-11 receptor subunit alpha |
NCBI Synonym Full Names: | interleukin 11 receptor, alpha |
NCBI Official Symbol: | IL11RA |
NCBI Official Synonym Symbols: | CRSDA |
NCBI Protein Information: | interleukin-11 receptor subunit alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha; interleukin-11 receptor alpha chain |
UniProt Protein Name: | Interleukin-11 receptor subunit alpha |
Protein Family: | Interleukin-11 receptor |
UniProt Gene Name: | IL11RA |
UniProt Entry Name: | I11RA_HUMAN |