IL10RA Antibody (PACO52370)
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주문- SKU:
- PACO52370
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL10RA Antibody (PACO52370) |
Antibody SKU: | PACO52370 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Interleukin-10 receptor subunit α protein (22-235AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of A549 cells using PACO52370 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Western Blot. Positive WB detected in: K562 whole cell lysate. All lanes: IL10RA antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 64 kDa. Observed band size: 64 kDa. |
Background: | Receptor for IL10; binds IL10 with a high affinity. |
Synonyms: | Interleukin-10 receptor subunit α (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210), IL10RA, IL10R |
UniProt Protein Function: | IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 11q23 Cellular Component: integral to membrane; plasma membrane Molecular Function:interleukin-10 binding; interleukin-10 receptor activity; protein binding; receptor activity; signal transducer activity Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide Disease: Inflammatory Bowel Disease 28, Autosomal Recessive |
NCBI Summary: | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] |
UniProt Code: | Q13651 |
NCBI GenInfo Identifier: | 322510034 |
NCBI Gene ID: | 3587 |
NCBI Accession: | Q13651.2 |
UniProt Secondary Accession: | Q13651,A8K6I0, B0YJ27, |
UniProt Related Accession: | Q13651 |
Molecular Weight: | |
NCBI Full Name: | Interleukin-10 receptor subunit alpha |
NCBI Synonym Full Names: | interleukin 10 receptor subunit alpha |
NCBI Official Symbol: | IL10RA |
NCBI Official Synonym Symbols: | CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1 |
NCBI Protein Information: | interleukin-10 receptor subunit alpha |
UniProt Protein Name: | Interleukin-10 receptor subunit alpha |
UniProt Synonym Protein Names: | CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD_antigen: CD210 |
Protein Family: | Interleukin-10 receptor |
UniProt Gene Name: | IL10RA |
UniProt Entry Name: | I10R1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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