IKBKB (Ab-199) Antibody (PACO22978)
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주문- SKU:
- PACO22978
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | IKBKB (Ab-199) Antibody (PACO22978) |
Antibody SKU: | PACO22978 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IF:1:100-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around aa.197~201 (Q-K-Y-T-V) derived from Human IKK-b. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from MDA cells using IKK-b(Ab-199) Antibody. | |
Immunofluorescence staining of methanol-fixed Hela cells using IKK-b(Ab-199) Antibody. |
Background: | Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3. |
Synonyms: | I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK2; IkBKB; NFKBIKB |
UniProt Protein Function: | IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft Molecular Function:protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis Disease: Immunodeficiency 15 |
NCBI Summary: | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | O14920 |
NCBI GenInfo Identifier: | 14285497 |
NCBI Gene ID: | 3551 |
NCBI Accession: | O14920.1 |
UniProt Secondary Accession: | O14920,O75327, B4DZ30, B4E0U4, |
UniProt Related Accession: | O14920 |
Molecular Weight: | 86,564 Da |
NCBI Full Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
NCBI Synonym Full Names: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
NCBI Official Symbol: | IKBKB |
NCBI Official Synonym Symbols: | IKK2; IKKB; IMD15; NFKBIKB; IKK-beta |
NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta |
UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
UniProt Synonym Protein Names: | I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta |
UniProt Gene Name: | IKBKB |
UniProt Entry Name: | IKKB_HUMAN |
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