IKBIP Antibody (PACO16531)
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주문- SKU:
- PACO16531
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IKBIP Antibody (PACO16531) |
Antibody SKU: | PACO16531 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human IKBIP |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16531(IKBIP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16531(IKBIP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle. |
Synonyms: | IKBKB interacting protein |
UniProt Protein Function: | Target of p53/TP53 with pro-apoptotic function. |
UniProt Code: | Q70UQ0 |
NCBI GenInfo Identifier: | 74712656 |
NCBI Gene ID: | 121457 |
NCBI Accession: | Q70UQ0.1 |
UniProt Secondary Accession: | Q70UQ0,Q6ZWH4, Q70UP9, Q86V91, Q96ND2, |
UniProt Related Accession: | Q70UQ0 |
Molecular Weight: | 43,084 Da |
NCBI Full Name: | Inhibitor of nuclear factor kappa-B kinase-interacting protein |
NCBI Synonym Full Names: | IKBKB interacting protein |
NCBI Official Symbol: | IKBIP |
NCBI Official Synonym Symbols: | IKIP |
NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase-interacting protein |
UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase-interacting protein |
Protein Family: | Inhibitor of nuclear factor kappa-B kinase-interacting protein |
UniProt Gene Name: | IKBIP |
UniProt Entry Name: | IKIP_HUMAN |