IFNL3 Antibody (PACO43915)
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주문- SKU:
- PACO43915
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IFNL3 Antibody (PACO43915) |
Antibody SKU: | PACO43915 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Interferon lambda-3 protein (22-196AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43915 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO43915 at dilution of 1:100. |
Background: | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
Synonyms: | Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C), IFNL3, IL28B IL28C ZCYTO22 |
UniProt Protein Function: | IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.13 Cellular Component: extracellular space Molecular Function:cytokine activity Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus Disease: Hepatitis C Virus, Susceptibility To |
NCBI Summary: | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8IZI9 |
NCBI GenInfo Identifier: | 300669648 |
NCBI Gene ID: | 282617 |
NCBI Accession: | Q8IZI9.2 |
UniProt Secondary Accession: | Q8IZI9,Q6VN56, Q7Z4J3, Q8IWL6, A2BDE1, |
UniProt Related Accession: | Q8IZI9 |
Molecular Weight: | 196 |
NCBI Full Name: | Interferon lambda-3 |
NCBI Synonym Full Names: | interferon, lambda 3 |
NCBI Official Symbol: | IFNL3 |
NCBI Official Synonym Symbols: | IL28B; IL28C; IL-28B |
NCBI Protein Information: | interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3) |
UniProt Protein Name: | Interferon lambda-3 |
UniProt Synonym Protein Names: | Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C; IL-28C |
Protein Family: | Interferon |
UniProt Gene Name: | IFNL3 |
UniProt Entry Name: | IFNL3_HUMAN |
Antibodies | ELISA Kits |
Anti-IFNL3 Antibody (CAB12908) | Human IL-28B / IL-28 beta ELISA Kit |
Anti-IFNL3 Antibody (CAB5648) | Human IL-28B ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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