IFITM1 Antibody (PACO02153)
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주문- SKU:
- PACO02153
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | IFITM1 Antibody |
Antibody SKU: | PACO02153 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the N-terminal region of human CD225. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | IFITM1; CD225; IFI17; Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD225 |
UniProt Protein Function: | IFITM1: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Belongs to the CD225/Dispanin family. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: membrane; integral to membrane; plasma membrane Molecular Function:protein binding; receptor signaling protein activity Biological Process: positive regulation of osteoblast differentiation; negative regulation of cell proliferation; regulation of immune response; ossification; cell surface receptor linked signal transduction; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; response to virus; defense response to virus; negative regulation of cell migration |
UniProt Code: | P13164 |
NCBI GenInfo Identifier: | 215274118 |
NCBI Gene ID: | 8519 |
NCBI Accession: | P13164.3 |
UniProt Secondary Accession: | P13164,Q15322, Q53XZ0, |
UniProt Related Accession: | P13164,AAB25699 |
Molecular Weight: | 125 |
NCBI Full Name: | Interferon-induced transmembrane protein 1 |
NCBI Synonym Full Names: | interferon induced transmembrane protein 1 |
NCBI Official Symbol: | IFITM1 |
NCBI Official Synonym Symbols: | 9-27; CD225; IFI17; LEU13; DSPA2a |
NCBI Protein Information: | interferon-induced transmembrane protein 1; leu-13 antigen; interferon-induced protein 17; dispanin subfamily A member 2a; interferon-inducible protein 9-27 |
UniProt Protein Name: | Interferon-induced transmembrane protein 1 |
UniProt Synonym Protein Names: | Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD_antigen: CD225 |
UniProt Gene Name: | IFITM1 |
UniProt Entry Name: | IFM1_HUMAN |