IFIT3 Antibody (PACO27509)
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주문- SKU:
- PACO27509
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IFIT3 Antibody (PACO27509) |
Antibody SKU: | PACO27509 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000, |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Interferon-induced protein with tetratricopeptide repeats 3 protein (1-490AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: A549 whole cell lysate All lanes: IFIT3 antibody at 3.3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 56 kDa Observed band size: 56 kDa . | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO27509 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO27509 at dilution of 1:100. |
Background: | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. |
Synonyms: | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid, induced gene G protein) (P60) (RIG-G), IFIT3, CIG-49 IFI60 IFIT4 ISG60 |
UniProt Protein Function: | IFIT3: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Belongs to the IFIT family. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 10q24 Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function:identical protein binding; protein binding Biological Process: negative regulation of cell proliferation; cytokine and chemokine mediated signaling pathway; response to virus; defense response to virus; negative regulation of apoptosis |
UniProt Code: | O14879 |
NCBI GenInfo Identifier: | 6831570 |
NCBI Gene ID: | 3437 |
NCBI Accession: | O14879.1 |
UniProt Secondary Accession: | O14879,Q99634, Q9BSK7, |
UniProt Related Accession: | O14879 |
Molecular Weight: | 490 |
NCBI Full Name: | Interferon-induced protein with tetratricopeptide repeats 3 |
NCBI Synonym Full Names: | interferon-induced protein with tetratricopeptide repeats 3 |
NCBI Official Symbol: | IFIT3 |
NCBI Official Synonym Symbols: | P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; CIG-49; GARG-49 |
NCBI Protein Information: | interferon-induced protein with tetratricopeptide repeats 3; CIG49; IFIT-3; IFIT-4; ISG-60; IFI-60K; interferon-induced 60 kDa protein; retinoic acid-induced gene G protein; interferon-induced protein with tetratricopeptide repeats 4 |
UniProt Protein Name: | Interferon-induced protein with tetratricopeptide repeats 3 |
UniProt Synonym Protein Names: | CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G |
Protein Family: | Interferon-induced protein with tetratricopeptide repeats |
UniProt Gene Name: | IFIT3 |
UniProt Entry Name: | IFIT3_HUMAN |