ID4 Antibody (PACO51622)
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주문- SKU:
- PACO51622
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ID4 Antibody (PACO51622) |
Antibody SKU: | PACO51622 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human DNA-binding protein inhibitor ID-4 protein (1-161AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of Hela cells using PACO51622 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). |
Synonyms: | DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4), ID4, BHLHB27 |
UniProt Protein Function: | ID4: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; protein dimerization activity; transcription corepressor activity Biological Process: cerebral cortex neuron differentiation; circadian rhythm; fat cell differentiation; G1/S transition of mitotic cell cycle; hippocampus development; myelination in the central nervous system; negative regulation of astrocyte differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuroblast proliferation; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011] |
UniProt Code: | P47928 |
NCBI GenInfo Identifier: | 1352422 |
NCBI Gene ID: | 3400 |
NCBI Accession: | P47928.1 |
UniProt Secondary Accession: | P47928,Q13005, |
UniProt Related Accession: | P47928 |
Molecular Weight: | 16,622 Da |
NCBI Full Name: | DNA-binding protein inhibitor ID-4 |
NCBI Synonym Full Names: | inhibitor of DNA binding 4, HLH protein |
NCBI Official Symbol: | ID4 |
NCBI Official Synonym Symbols: | IDB4; bHLHb27 |
NCBI Protein Information: | DNA-binding protein inhibitor ID-4 |
UniProt Protein Name: | DNA-binding protein inhibitor ID-4 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 27; bHLHb27; Inhibitor of DNA binding 4; Inhibitor of differentiation 4 |
Protein Family: | DNA-binding protein inhibitor |
UniProt Gene Name: | ID4 |
UniProt Entry Name: | ID4_HUMAN |
Antibodies | ELISA Kits |
Anti-ID4 Antibody (CAB16229) | ID4 Colorimetric Cell-Based ELISA |
ID4 Antibody (PACO00947) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |