HVCN1 Antibody (PACO45293)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO45293
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HVCN1 Antibody (PACO45293) |
Antibody SKU: | PACO45293 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Voltage-gated hydrogen channel 1 protein (1-100AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: HVCN1 antibody at 1.17µg/ml + Raji whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 28, 30 kDa. Observed band size: 32 kDa.. | |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO45293 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45293 at dilution of 1:100. |
Background: | Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. |
Synonyms: | Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein), HVCN1, VSOP |
UniProt Protein Function: | HVCN1: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Belongs to the hydrogen channel family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, cation Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:voltage-gated cation channel activity; voltage-gated proton channel activity Biological Process: proton transport; response to pH; response to zinc ion; sperm-egg recognition |
NCBI Summary: | This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q96D96 |
NCBI GenInfo Identifier: | 74751810 |
NCBI Gene ID: | 84329 |
NCBI Accession: | Q96D96.1 |
UniProt Secondary Accession: | Q96D96,Q6UW11, Q96IS5, A8MQ37, B4DEB3, F8WCH5, |
UniProt Related Accession: | Q96D96 |
Molecular Weight: | 29,415 Da |
NCBI Full Name: | Voltage-gated hydrogen channel 1 |
NCBI Synonym Full Names: | hydrogen voltage gated channel 1 |
NCBI Official Symbol: | HVCN1 |
NCBI Official Synonym Symbols: | HV1; VSOP |
NCBI Protein Information: | voltage-gated hydrogen channel 1 |
UniProt Protein Name: | Voltage-gated hydrogen channel 1 |
UniProt Synonym Protein Names: | Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein |
Protein Family: | Voltage-gated hydrogen channel |
UniProt Gene Name: | HVCN1 |
UniProt Entry Name: | HVCN1_HUMAN |