Human TNF-alpha/TNFA Recombinant Protein (RPES4122)

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SKU:
RPES4122
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human TNF-alpha/TNFA Recombinant Protein

TNF? is a homotrimer with a subunit molecular mass of 17 kD cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It plays a major role in growth regulation; differentiation; inflammation; viral replication; tumorigenesis; autoimmune diseases and in viral; bacterial; fungal; and parasitic infections. Besides inducing hemorrhagic necrosis of tumors; TNF was found to be involved in tumorigenesis; tumor metastasis; viral replication; septic shock; fever; inflammation; and autoimmune diseases including Crohn’s disease; and rheumatoid arthritis as well as graft-versus-host disease.

Product Name:Human TNF-alpha/TNFA Recombinant Protein (RPES4122)
Product Code:RPES4122
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Tumor Necrosis Factor, Cachectin, TNF-Alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFA, TNFSF2
Accession:P01375
Sequence:Val77-Leu233
Activity:Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 10-50 pg/ml.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human TNF-alpha is produced by our E.coli expression system and the target gene encoding Val77-Leu233 is expressed.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:17.5 kDa
AP Mol Mass:16 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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