IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
Product Name:
Human IGF/IGF-I/IGF1 Recombinant Protein (RPES0732)
Product Code:
RPES0732
Size:
100µg
Species:
Human
Expressed Host:
Yeast
Synonyms:
IGF-1,IGF-I,IGF1A,IGFI,IGF?I,MGF
Accession:
NP_001104754.1
Sequence:
Gly49-Ala118
Fusion tag:
Activity:
Measured in a cell proliferation assay using MCF-7 cells. The ED50?for this effect is 15-60ng/mL.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human IGF1 (NP_001104754.1) (Gly49-Ala118) was expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
7.7 kDa
Formulation:
Lyophilized from sterile PBS,pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_alt데이터시트Human IGF/IGF1 Recombinant Protein Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. M
system_update_alt데이터시트Mouse IGF1/IGF-1/IGF Recombinant Protein IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family