YWHAE; also known as 14-3-3 epsilon; mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism; protein trafficking; signal transduction; apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm; and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals; and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases; RAF1 and IRS1 proteins; suggesting its role in diverse biochemical activities related to signal transduction; such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners; usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.
Product Name:
Human 14-3-3 epsilon/YWHAE Recombinant Protein (RPES2765)
Product Code:
RPES2765
Size:
50µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
14-3-3E,HEL2,KCIP-1,MDCR,MDS
Accession:
NP_006752.1
Sequence:
Met 1-Gln 255
Fusion tag:
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human YWHAE (NP_006752.1) (Met 1-Gln 255) was expressed; with two additional amino acids (Gly & Pro) at the N-terminus.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_alt데이터시트Human CD3 Epsilon/CD3E Recombinant Protein T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-li
system_update_alt데이터시트Human CD3 Epsilon/CD3E Recombinant Protein T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-li
system_update_alt데이터시트Human CD3 Epsilon/CD3E Recombinant Protein T-Cell Surface Glycoprotein CD3 ? Chain (CD3?) is a single-pass type I membrane protein. CD3? contains 1 Ig-like (immunoglobulin-l
system_update_alt데이터시트Human 14-3-3 eta/YWHAH Recombinant Protein YWHAH, the gene encoding the 14-3-3eta isoform, is highly expressed in retinal ganglion cells (RGC). YWHAH is a positional and fun
system_update_alt데이터시트Human 14-3-3 sigma/YWHAS Recombinant Protein 14-3-3 protein sigma (YWHAS); also known as stratifin (SFN) and epithelial cell marker protein 1; is a member of the14-3-3 prot