UniProt Protein Function: | 5-HT(3B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Chromosomal Location of Human Ortholog: 11q23.2 Cellular Component: cell surface; plasma membrane Molecular Function:serotonin receptor activity; serotonin-gated cation channel activity Biological Process: serotonin receptor signaling pathway |
NCBI Summary: | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011] |
UniProt Code: | O95264 |
NCBI GenInfo Identifier: | 74705987 |
NCBI Gene ID: | 9177 |
NCBI Accession: | O95264.1 |
UniProt Secondary Accession: | O95264,Q0VJC3, B0YJ23, |
UniProt Related Accession: | O95264 |
Molecular Weight: | 50kDa |
NCBI Full Name: | 5-hydroxytryptamine receptor 3B |
NCBI Synonym Full Names: | 5-hydroxytryptamine receptor 3B |
NCBI Official Symbol: | HTR3B |
NCBI Official Synonym Symbols: | 5-HT3B |
NCBI Protein Information: | 5-hydroxytryptamine receptor 3B |
UniProt Protein Name: | 5-hydroxytryptamine receptor 3B |
UniProt Synonym Protein Names: | Serotonin receptor 3B |
Protein Family: | 5-hydroxytryptamine receptor |
UniProt Gene Name: | HTR3B |