HTATIP2 Antibody (PACO43198)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43198
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HTATIP2 Antibody (PACO43198) |
Antibody SKU: | PACO43198 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Oxidoreductase HTATIP2 protein (1-230AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO43198 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43198 at dilution of 1:100. |
Background: | Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. |
Synonyms: | Oxidoreductase HTATIP2 (EC 1.1.1.-) (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2), HTATIP2, CC3 TIP30 |
UniProt Protein Function: | HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oxidoreductase; Apoptosis; Tumor suppressor; Nuclear envelope; Transcription factor; EC 1.1.1.- Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus Molecular Function:protein binding; transcription coactivator activity; oxidoreductase activity Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis |
UniProt Code: | Q9BUP3 |
NCBI GenInfo Identifier: | 317373366 |
NCBI Gene ID: | 10553 |
NCBI Accession: | Q9BUP3.2 |
UniProt Secondary Accession: | Q9BUP3,O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3 A8K7S7, D3DQY8, |
UniProt Related Accession: | Q9BUP3 |
Molecular Weight: | 242 |
NCBI Full Name: | Oxidoreductase HTATIP2 |
NCBI Synonym Full Names: | HIV-1 Tat interactive protein 2, 30kDa |
NCBI Official Symbol: | HTATIP2 |
NCBI Official Synonym Symbols: | CC3; TIP30; SDR44U1 |
NCBI Protein Information: | oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1 |
UniProt Protein Name: | Oxidoreductase HTATIP2 |
UniProt Synonym Protein Names: | 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 |
Protein Family: | Oxidoreductase |
UniProt Gene Name: | HTATIP2 |
UniProt Entry Name: | HTAI2_HUMAN |