HSPH1 Antibody (PACO14542)
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주문- SKU:
- PACO14542
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HSPH1 Antibody (PACO14542) |
Antibody SKU: | PACO14542 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human HSPH1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: PC3 cells, human colon cancer tissue, Human liver cancer tissue, Primary antibody: PACO14542(HSPH1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
Background: | Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |
Synonyms: | Heat shock 105kDa/110kDa protein 1 |
UniProt Protein Function: | HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 13q12.3 Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol Molecular Function:protein binding; ATP binding; alpha-tubulin binding Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein |
UniProt Code: | Q92598 |
NCBI GenInfo Identifier: | 2495344 |
NCBI Gene ID: | 10808 |
NCBI Accession: | Q92598.1 |
UniProt Secondary Accession: | Q92598,O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q9UPC4, B4DYH1 |
UniProt Related Accession: | Q92598 |
Molecular Weight: | 97,460 Da |
NCBI Full Name: | Heat shock protein 105 kDa |
NCBI Synonym Full Names: | heat shock 105kDa/110kDa protein 1 |
NCBI Official Symbol: | HSPH1 |
NCBI Official Synonym Symbols: | HSP105; HSP105A; HSP105B; NY-CO-25 |
NCBI Protein Information: | heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha |
UniProt Protein Name: | Heat shock protein 105 kDa |
UniProt Synonym Protein Names: | Antigen NY-CO-25; Heat shock 110 kDa protein |
Protein Family: | Heat shock protein |
UniProt Gene Name: | HSPH1 |
UniProt Entry Name: | HS105_HUMAN |
Antibodies |
Anti-HSPH1 Antibody (CAB6622) |
Anti-HSPH1 Antibody (CAB19914)[KO Validated] |
Anti-Hsp105 Antibody (CAB4687) |
HSPH1 Antibody (PACO00945) |
HSPH1 Antibody (PACO09836) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |