HSD17B4 Antibody (PACO16491)
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주문- SKU:
- PACO16491
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | HSD17B4 Antibody (PACO16491) |
Antibody SKU: | PACO16491 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human HSD17B4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16491(HSD17B4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Huvec cells, K562 cells, Primary antibody: PACO16491(HSD17B4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16491(HSD17B4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acid, . It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acid, . Defects in this gene that affect the peroxisomal fatty acid, beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. |
Synonyms: | hydroxysteroid (17-beta) dehydrogenase 4 |
UniProt Protein Function: | HSD17B4: Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD). DBPD is a disorder of peroxisomal fatty acid beta-oxidation. Defects in HSD17B4 are the cause of Perrault syndrome (PRS). PRS is a sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
UniProt Protein Details: | Protein type:EC 4.2.1.107; Lyase; Oxidoreductase; Cell development/differentiation; EC 4.2.1.119; Lipid Metabolism - primary bile acid biosynthesis; EC 1.1.1.n12; Mitochondrial Chromosomal Location of Human Ortholog: 5q21 Cellular Component: intracellular membrane-bound organelle; membrane; peroxisomal matrix; peroxisomal membrane; peroxisome Molecular Function:3-hydroxyacyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; long-chain-enoyl-CoA hydratase activity; protein homodimerization activity; receptor binding Biological Process: androgen metabolic process; bile acid biosynthetic process; estrogen metabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; osteoblast differentiation Disease: D-bifunctional Protein Deficiency; Perrault Syndrome 1 |
NCBI Summary: | The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
UniProt Code: | P51659 |
NCBI GenInfo Identifier: | 1706396 |
NCBI Gene ID: | 3295 |
NCBI Accession: | P51659.3 |
UniProt Secondary Accession: | P51659,B4DNV1, B4DVS5, E9PB82, F5HE57, |
UniProt Related Accession: | P51659 |
Molecular Weight: | 77,870 Da |
NCBI Full Name: | Peroxisomal multifunctional enzyme type 2 |
NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 4 |
NCBI Official Symbol: | HSD17B4 |
NCBI Official Synonym Symbols: | DBP; MFE-2; MPF-2; PRLTS1; SDR8C1 |
NCBI Protein Information: | peroxisomal multifunctional enzyme type 2 |
UniProt Protein Name: | Peroxisomal multifunctional enzyme type 2 |
UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4 |
UniProt Gene Name: | HSD17B4 |
UniProt Entry Name: | DHB4_HUMAN |