HR Antibody (PACO23725)
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주문- SKU:
- PACO23725
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HR Antibody (PACO23725) |
Antibody SKU: | PACO23725 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human HAIR. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 293 cells, using HAIR antibody. | |
Immunofluorescence analysis of A549 cells, using HAIR antibody. | |
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HAIR antibody. |
Background: | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. |
Synonyms: | Protein hairless; HR; HAIR; |
UniProt Protein Function: | HR: May act as a transcription factor that could act on to regulate one of the phases of hair growth. Defects in HR are the cause of alopecia universalis congenita (ALUNC). ALUNC is a rare autosomal recessive form of hair loss characterized by hair follicles without hair. Defects in HR are the cause of atrichia with papular lesions (APL); also known as congenital atrichia. APL is an autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair. Defects in HR are the cause of hypotrichosis type 4 (HYPT4). An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: chromatin; nucleoplasm; nucleus Molecular Function:chromatin DNA binding; histone demethylase activity (H3-K9 specific) Biological Process: histone H3-K9 demethylation; regulation of transcription, DNA-dependent Disease: Alopecia Universalis Congenita; Atrichia With Papular Lesions; Hypotrichosis 4 |
NCBI Summary: | This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |
UniProt Code: | O43593 |
NCBI GenInfo Identifier: | 115502396 |
NCBI Gene ID: | 55806 |
NCBI Accession: | O43593.5 |
UniProt Secondary Accession: | O43593,Q6GS30, Q96H33, Q9NPE1, |
UniProt Related Accession: | O43593 |
Molecular Weight: | 127kDa |
NCBI Full Name: | Lysine-specific demethylase hairless |
NCBI Synonym Full Names: | HR, lysine demethylase and nuclear receptor corepressor |
NCBI Official Symbol: | HR |
NCBI Official Synonym Symbols: | AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165 |
NCBI Protein Information: | lysine-specific demethylase hairless |
UniProt Protein Name: | Lysine-specific demethylase hairless |
Protein Family: | Hrp65 protein |
UniProt Gene Name: | HR |