HMGCS1 Antibody (PACO19765)
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주문- SKU:
- PACO19765
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HMGCS1 Antibody (PACO19765) |
Antibody SKU: | PACO19765 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human HMGCS1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19765(HMGCS1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19765(HMGCS1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acid, increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4. |
Synonyms: | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
UniProt Code: | Q01581 |
NCBI GenInfo Identifier: | 1708239 |
NCBI Gene ID: | 3157 |
NCBI Accession: | Q01581.2 |
UniProt Related Accession: | Q01581 |
Molecular Weight: | |
NCBI Full Name: | Hydroxymethylglutaryl-CoA synthase, cytoplasmic |
NCBI Synonym Full Names: | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
NCBI Official Symbol: | HMGCS1 |
NCBI Official Synonym Symbols: | HMGCS |
NCBI Protein Information: | hydroxymethylglutaryl-CoA synthase, cytoplasmic |
UniProt Protein Name: | Hydroxymethylglutaryl-CoA synthase, cytoplasmic |
UniProt Synonym Protein Names: | 3-hydroxy-3-methylglutaryl coenzyme A synthase |
UniProt Gene Name: | HMGCS1 |
UniProt Entry Name: | HMCS1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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