HMGB3 Antibody (PACO18072)
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주문- SKU:
- PACO18072
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HMGB3 Antibody (PACO18072) |
Antibody SKU: | PACO18072 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:10000, WB:1:500-1:2000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human HMGB3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18072(HMGB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-4: 293T cells, hela cells, mouse lung tissue, Mouse brain tissue, Primary antibody: PACO18072(HMGB3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1.5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18072(HMGB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene. HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 and HMG2, HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription. |
Synonyms: | high mobility group box 3 |
UniProt Protein Function: | HMGB3: Binds preferentially single-stranded DNA and unwinds double stranded DNA. Belongs to the HMGB family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq28 Molecular Function:DNA bending activity; double-stranded DNA binding; four-way junction DNA binding; protein binding Biological Process: DNA geometric change; DNA recombination; multicellular organismal development Disease: Microphthalmia, Syndromic 13 |
NCBI Summary: | This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | O15347 |
NCBI GenInfo Identifier: | 85701353 |
NCBI Gene ID: | 3149 |
NCBI Accession: | O15347.4 |
UniProt Secondary Accession: | O15347,O95556, Q6NS40, |
UniProt Related Accession: | O15347 |
Molecular Weight: | 22,980 Da |
NCBI Full Name: | High mobility group protein B3 |
NCBI Synonym Full Names: | high mobility group box 3 |
NCBI Official Symbol: | HMGB3 |
NCBI Official Synonym Symbols: | HMG4; HMG-4; HMG2A; HMG-2a |
NCBI Protein Information: | high mobility group protein B3 |
UniProt Protein Name: | High mobility group protein B3 |
UniProt Synonym Protein Names: | High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 |
Protein Family: | High mobility group protein |
UniProt Gene Name: | HMGB3 |
Antibodies | ELISA Kits |
Anti-HMGB3 Antibody (CAB15064) | Human HMGB3 / High mobility group protein B3 ELISA Kit |
Human High mobility group protein B3 (HMGB3) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |