HCAR2 Antibody (PACO19728)
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주문- SKU:
- PACO19728
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HCAR2 Antibody (PACO19728) |
Antibody SKU: | PACO19728 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human HCAR2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19728(HCAR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19728(HCAR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | HCAR2, also known as PUMAG or Puma-g, is a member of the G protein coupled receptor (GPCR) superfamily. HCAR2 is highly expressed in adipocytes, immune cells and spleen. Like all members of the GPCR superfamily, HCAR2 contains seven transmembrane domains. |
Synonyms: | hydroxycarboxylic acid, receptor 2 |
UniProt Protein Function: | GPR109A: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cell junction; plasma membrane Biological Process: negative regulation of lipid catabolic process; neutrophil apoptosis; positive regulation of neutrophil apoptosis |
UniProt Code: | Q8TDS4 |
NCBI GenInfo Identifier: | 74762622 |
NCBI Gene ID: | 338442 |
NCBI Accession: | Q8TDS4.1 |
UniProt Secondary Accession: | Q8TDS4,A0PJL5, A7LGG3, |
UniProt Related Accession: | Q8TDS4 |
Molecular Weight: | 41,850 Da |
NCBI Full Name: | Hydroxycarboxylic acid receptor 2 |
NCBI Synonym Full Names: | hydroxycarboxylic acid receptor 2 |
NCBI Official Symbol: | HCAR2 |
NCBI Official Synonym Symbols: | HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A |
NCBI Protein Information: | hydroxycarboxylic acid receptor 2 |
UniProt Protein Name: | Hydroxycarboxylic acid receptor 2 |
UniProt Synonym Protein Names: | G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor |
Protein Family: | Hydroxycarboxylic acid receptor |
UniProt Gene Name: | HCAR2 |
UniProt Entry Name: | HCAR2_HUMAN |
Antibodies |
Anti-HCAR2 Antibody (CAB15611) |
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