GZMB Antibody (PACO14482)
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주문- SKU:
- PACO14482
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GZMB Antibody (PACO14482) |
Antibody SKU: | PACO14482 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human GZMB |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14482(GZMB Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. |
Synonyms: | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
UniProt Protein Function: | GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily. |
UniProt Protein Details: | Protein type:Apoptosis; EC 3.4.21.79; Protease Chromosomal Location of Human Ortholog: 14q12 Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; nucleus Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: apoptosis; natural killer cell mediated cytotoxicity; protein processing |
NCBI Summary: | This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016] |
UniProt Code: | P10144 |
NCBI GenInfo Identifier: | 317373361 |
NCBI Gene ID: | 3002 |
NCBI Accession: | P10144.2 |
UniProt Secondary Accession: | P10144,Q8N1D2, Q9UCC1, |
UniProt Related Accession: | P10144 |
Molecular Weight: | |
NCBI Full Name: | Granzyme B |
NCBI Synonym Full Names: | granzyme B |
NCBI Official Symbol: | GZMB |
NCBI Official Synonym Symbols: | C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1 |
NCBI Protein Information: | granzyme B |
UniProt Protein Name: | Granzyme B |
UniProt Synonym Protein Names: | C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E |
Protein Family: | Granzyme |
UniProt Gene Name: | GZMB |
Antibodies | ELISA Kits |
Anti-GZMB Antibody (CAB2557) | Human GR beta / Glucocorticoid Receptor Beta ELISA Kit |
Anti-Granzyme B Antibody (CAB19592) | Human Granzyme B (GZMB) ELISA Kit |
GZMB Antibody (PACO09655) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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