GYPC Antibody (PACO16435)
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주문- SKU:
- PACO16435
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GYPC Antibody (PACO16435) |
Antibody SKU: | PACO16435 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human GYPC |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16435(GYPC Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16435(GYPC Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. |
Synonyms: | glycophorin C |
UniProt Protein Function: | GYPC: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. Belongs to the glycophorin-C family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q14-q21 Cellular Component: cortical cytoskeleton; membrane; integral to plasma membrane; plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Blood Group, Gerbich System |
NCBI Summary: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
UniProt Code: | P04921 |
NCBI GenInfo Identifier: | 121407 |
NCBI Gene ID: | 2995 |
NCBI Accession: | P04921.1 |
UniProt Secondary Accession: | P04921,Q53SV9, Q92642, B2R522, |
UniProt Related Accession: | P04921 |
Molecular Weight: | 128 |
NCBI Full Name: | Glycophorin-C |
NCBI Synonym Full Names: | glycophorin C (Gerbich blood group) |
NCBI Official Symbol: | GYPC |
NCBI Official Synonym Symbols: | GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2' |
NCBI Protein Information: | glycophorin-C; glycophorin-D; glycoconnectin; glycoprotein beta; sialoglycoprotein D |
UniProt Protein Name: | Glycophorin-C |
UniProt Synonym Protein Names: | Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD_antigen: CD236 |
Protein Family: | Glycophorin |
UniProt Gene Name: | GYPC |
UniProt Entry Name: | GLPC_HUMAN |