GUCY2C Antibody (PACO47446)
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주문- SKU:
- PACO47446
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GUCY2C Antibody (PACO47446) |
Antibody SKU: | PACO47446 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Heat-stable enterotoxin receptor protein (636-891AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO47446 at dilution of 1:100. | |
Western Blot. Positive WB detected in: HEK293 whole cell lysate, Mouse liver tissue, Mouse brain tissue. All lanes: GUCY2C antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 124 kDa. Observed band size: 124 kDa. | |
Immunofluorescent analysis of HepG2 cells using PACO47446 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. |
Synonyms: | Heat-stable enterotoxin receptor (STA receptor) (hSTAR) (EC 4.6.1.2) (Guanylyl cyclase C) (GC-C) (Intestinal guanylate cyclase), GUCY2C, GUC2C STAR |
UniProt Protein Function: | GUCY2C: an intestinal receptor for the E.coli enterotoxin, and the paracrine hormones guanylin and uroguanylin. Regulates intestinal cell proliferation. Converts guanosine-5'-triphosphate to cyclic guanosine monophosphate (cGMP). Elevated intracellular cGMP modulates intestinal fluid-ion homeostasis and differentiation of crypt enterocytes. cGMP inhibits colonic cell proliferation by inducing p21 and cell cycle arrest. mice lacking GC-C display increased cell proliferation in colonic crypts. It functions as a tumor suppressor; its loss disrupts intestinal homeostasis and promotes tumorigenesis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
UniProt Protein Details: | Protein type:EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc. Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: guanylate cyclase complex, soluble; plasma membrane Molecular Function:adenylate cyclase activity; guanylate cyclase activity; protein binding Biological Process: cGMP biosynthetic process; digestion; receptor guanylyl cyclase signaling pathway Disease: Diarrhea 6; Meconium Ileus |
NCBI Summary: | This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016] |
UniProt Code: | P25092 |
NCBI GenInfo Identifier: | 311033390 |
NCBI Gene ID: | 2984 |
NCBI Accession: | P25092.2 |
UniProt Secondary Accession: | P25092,B2RMY6, |
UniProt Related Accession: | P25092 |
Molecular Weight: | 123kDa |
NCBI Full Name: | Heat-stable enterotoxin receptor |
NCBI Synonym Full Names: | guanylate cyclase 2C |
NCBI Official Symbol: | GUCY2C |
NCBI Official Synonym Symbols: | GC-C; STAR; DIAR6; GUC2C; MECIL; MUCIL |
NCBI Protein Information: | heat-stable enterotoxin receptor |
UniProt Protein Name: | Heat-stable enterotoxin receptor |
UniProt Synonym Protein Names: | Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase |
Protein Family: | Heat-stable enterotoxin receptor |
UniProt Gene Name: | GUCY2C |
Antibodies | ELISA Kits |
Anti-GUCY2C Antibody (CAB10562) | Human GUCY2C / Heat-stable enterotoxin receptor ELISA Kit |
Human Heat-stable enterotoxin receptor (GUCY2C) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |