GTF2A2 Antibody (PACO44644)
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주문- SKU:
- PACO44644
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | GTF2A2 Antibody (PACO44644) |
Antibody SKU: | PACO44644 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Transcription initiation factor IIA subunit 2 protein (1-109AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44644 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO44644 at dilution of 1:100. |
Background: | TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. |
Synonyms: | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA γ chain) (TFIIA-gamma), GTF2A2, TF2A2 |
UniProt Protein Function: | GTF2A2: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Belongs to the TFIIA subunit 2 family. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q22.2 Cellular Component: cell junction; nucleoplasm; transcription factor TFIIA complex Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; TATA-binding protein binding; transcription coactivator activity; transcription factor binding Biological Process: positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcriptional preinitiation complex assembly; viral reproduction |
NCBI Summary: | Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008] |
UniProt Code: | P52657 |
NCBI GenInfo Identifier: | 49457380 |
NCBI Gene ID: | 2958 |
NCBI Accession: | CAG46989.1 |
UniProt Related Accession: | P52657 |
Molecular Weight: | |
NCBI Full Name: | GTF2A2, partial |
NCBI Synonym Full Names: | general transcription factor IIA subunit 2 |
NCBI Official Symbol: | GTF2A2 |
NCBI Official Synonym Symbols: | TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma |
NCBI Protein Information: | transcription initiation factor IIA subunit 2 |
UniProt Protein Name: | Transcription initiation factor IIA subunit 2 |
UniProt Synonym Protein Names: | General transcription factor IIA subunit 2; TFIIA p12 subunit; TFIIA-12; TFIIAS; Transcription initiation factor IIA gamma chain; TFIIA-gamma |
UniProt Gene Name: | GTF2A2 |
UniProt Entry Name: | T2AG_HUMAN |