GSTA3 Antibody (PACO16452)
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주문- SKU:
- PACO16452
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GSTA3 Antibody (PACO16452) |
Antibody SKU: | PACO16452 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human GSTA3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16452(GSTA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO16452(GSTA3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16452(GSTA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the α class genes that are located in a cluster mapped to chromosome 6. Genes of the α class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this α class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. |
Synonyms: | glutathione S-transferase α 3 |
UniProt Protein Function: | GSTA3: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Belongs to the GST superfamily. Alpha family. |
UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Transferase Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: cytosol Molecular Function:glutathione transferase activity Biological Process: glutathione metabolic process |
NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16772 |
NCBI GenInfo Identifier: | 21264437 |
NCBI Gene ID: | 2940 |
NCBI Accession: | Q16772.3 |
UniProt Secondary Accession: | Q16772,O43468, Q068V6, Q8WWA8, Q9H415, |
UniProt Related Accession: | Q16772 |
Molecular Weight: | 25,302 Da |
NCBI Full Name: | Glutathione S-transferase A3 |
NCBI Synonym Full Names: | glutathione S-transferase alpha 3 |
NCBI Official Symbol: | GSTA3 |
NCBI Official Synonym Symbols: | GTA3; GSTA3-3 |
NCBI Protein Information: | glutathione S-transferase A3 |
UniProt Protein Name: | Glutathione S-transferase A3 |
UniProt Synonym Protein Names: | GST class-alpha member 3; Glutathione S-transferase A3-3 |
Protein Family: | Glutathione S-transferase |
UniProt Gene Name: | GSTA3 |
UniProt Entry Name: | GSTA3_HUMAN |
Antibodies | ELISA Kits |
Anti-GSTA3 Antibody (CAB17491) | Human GSTA3 / Glutathione S-transferase A3 ELISA Kit |
GSTA3 Antibody (PACO09611) | Human Glutathione S-transferase A3 (GSTA3) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |