GSDME Antibody (PACO43576)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43576
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GSDME Antibody (PACO43576) |
Antibody SKU: | PACO43576 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Gasdermin-E protein (1-260AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43576 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43576 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43576 at dilution of 1:100. |
Background: | Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. |
Synonyms: | Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)], GSDME, DFNA5 ICERE1 |
UniProt Protein Function: | DFNA5: Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Defects in DFNA5 are the cause of deafness autosomal dominant type 5 (DFNA5). DFNA5 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Is a tumor suppressor gene with an important role in major types of tumors. Could be a valuable molecular marker in cancer. Belongs to the gasdermin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 7p15 Cellular Component: cytoplasm Biological Process: negative regulation of cell proliferation; sensory perception of sound; inner ear receptor cell differentiation; apoptosis Disease: Deafness, Autosomal Dominant 5 |
NCBI Summary: | Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60443 |
NCBI GenInfo Identifier: | 13124046 |
NCBI Gene ID: | 1687 |
NCBI Accession: | O60443.2 |
UniProt Secondary Accession: | O60443,O14590, Q08AQ8, Q9UBV3, A4D156, B2RAX9, B3KT05 |
UniProt Related Accession: | O60443 |
Molecular Weight: | 496 |
NCBI Full Name: | Non-syndromic hearing impairment protein 5 |
NCBI Synonym Full Names: | deafness, autosomal dominant 5 |
NCBI Official Symbol: | DFNA5 |
NCBI Official Synonym Symbols: | ICERE-1 |
NCBI Protein Information: | non-syndromic hearing impairment protein 5; nonsyndromic hearing impairment protein; inversely correlated with estrogen receptor expression 1 |
UniProt Protein Name: | Non-syndromic hearing impairment protein 5 |
UniProt Synonym Protein Names: | Inversely correlated with estrogen receptor expression 1; ICERE-1 |
Protein Family: | Non-syndromic hearing impairment protein |
UniProt Gene Name: | DFNA5 |
UniProt Entry Name: | DFNA5_HUMAN |