UniProt Protein Function: | GRP: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear. Belongs to the bombesin/neuromedin-B/ranatensin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 18q21.1-q21.32 Cellular Component: extracellular space; extracellular region Molecular Function:neuropeptide hormone activity; receptor binding Biological Process: neuropeptide signaling pathway; signal transduction |
NCBI Summary: | This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | P07492 |
NCBI GenInfo Identifier: | 308153451 |
NCBI Gene ID: | 2922 |
NCBI Accession: | P07492.2 |
UniProt Secondary Accession: | P07492,P07491, P81553, Q14454, Q53YA0, Q9BSY7, |
UniProt Related Accession: | P07492 |
Molecular Weight: | 148 |
NCBI Full Name: | Gastrin-releasing peptide |
NCBI Synonym Full Names: | gastrin-releasing peptide |
NCBI Official Symbol: | GRP |
NCBI Official Synonym Symbols: | BN; GRP-10; proGRP; preproGRP |
NCBI Protein Information: | gastrin-releasing peptide; bombesin; prepro-GRP; neuromedin C; pre-progastrin releasing peptide |
UniProt Protein Name: | Gastrin-releasing peptide |
UniProt Synonym Protein Names: | GRP-10 |
Protein Family: | GrpE protein |
UniProt Gene Name: | GRP |
UniProt Entry Name: | GRP_HUMAN |