GRM8 Antibody (PACO03998)
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주문- SKU:
- PACO03998
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GRM8 Antibody |
Antibody SKU: | PACO03998 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the C-terminal region of human mGluR-8. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GRM8; GPRC1H; MGLUR8; Metabotropic glutamate receptor 8; mGluR8 |
UniProt Protein Function: | mGluR8: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q31.3-q32.1 Cellular Component: integral to plasma membrane; plasma membrane; presynaptic membrane Molecular Function:G-protein coupled receptor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity Biological Process: metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; regulation of synaptic transmission, glutamatergic; visual perception |
NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00222 |
NCBI GenInfo Identifier: | 12644040 |
NCBI Gene ID: | 2918 |
NCBI Accession: | O00222.2 |
UniProt Secondary Accession: | O00222,O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165 A4D0Y3, B0FZ74, B0M0L0, |
UniProt Related Accession: | O00222 |
Molecular Weight: | 55,948 Da |
NCBI Full Name: | Metabotropic glutamate receptor 8 |
NCBI Synonym Full Names: | glutamate metabotropic receptor 8 |
NCBI Official Symbol: | GRM8 |
NCBI Official Synonym Symbols: | GLUR8; mGlu8; GPRC1H; MGLUR8 |
NCBI Protein Information: | metabotropic glutamate receptor 8 |
UniProt Protein Name: | Metabotropic glutamate receptor 8 |
Protein Family: | Metabotropic glutamate receptor |
UniProt Gene Name: | GRM8 |
UniProt Entry Name: | GRM8_HUMAN |