GPS1 Antibody (PACO43913)
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주문- SKU:
- PACO43913
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GPS1 Antibody (PACO43913) |
Antibody SKU: | PACO43913 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human COP9 signalosome complex subunit 1 protein (222-491AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: GPS1 antibody at 5µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 56, 60 kDa. Observed band size: 56 kDa. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO43913 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43913 at dilution of 1:100. |
Background: | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
Synonyms: | COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH), GPS1, COPS1 CSN1 |
UniProt Protein Function: | COPS1: a protein that suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. |
UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: signalosome; cytoplasm; nucleus Molecular Function:protein binding; GTPase inhibitor activity Biological Process: cullin deneddylation; JNK cascade; cell cycle; inactivation of MAPK activity |
NCBI Summary: | This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13098 |
NCBI GenInfo Identifier: | 223590263 |
NCBI Gene ID: | 2873 |
NCBI Accession: | Q13098.4 |
UniProt Secondary Accession: | Q13098,Q8NA10, Q9BWL1, |
UniProt Related Accession: | Q13098 |
Molecular Weight: | 491 |
NCBI Full Name: | COP9 signalosome complex subunit 1 |
NCBI Synonym Full Names: | G protein pathway suppressor 1 |
NCBI Official Symbol: | GPS1 |
NCBI Official Synonym Symbols: | CSN1; COPS1 |
NCBI Protein Information: | COP9 signalosome complex subunit 1; SGN1; GPS-1; signalosome subunit 1; COP9 signalosome subunit 1; JAB1-containing signalosome subunit 1 |
UniProt Protein Name: | COP9 signalosome complex subunit 1 |
UniProt Synonym Protein Names: | G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH |
UniProt Gene Name: | GPS1 |
UniProt Entry Name: | CSN1_HUMAN |
Antibodies |
Anti-GPS1 Antibody (CAB6917) |
Phospho-GPS1 (S454) Antibody (PACO03959) |
GPS1 Antibody (PACO03960) |
GPS1 Antibody (PACO09571) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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