GOSR1 Antibody (PACO43911)
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주문- SKU:
- PACO43911
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GOSR1 Antibody (PACO43911) |
Antibody SKU: | PACO43911 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Golgi SNAP receptor complex member 1 protein (1-115AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43911 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43911 at dilution of 1:100. |
Background: | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. |
Synonyms: | Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28), GOSR1, GS28 |
UniProt Protein Function: | GOSR1: a single-pass type IV Golgi membrane protein. Enriched on vesicular components at the terminal rims of the Golgi. Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR2, STX5, GABARAPL2 and YKT6. |
UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral; Autophagy Chromosomal Location of Human Ortholog: 17q11 Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; cis-Golgi network; membrane; integral to membrane Molecular Function:SNAP receptor activity Biological Process: intra-Golgi vesicle-mediated transport; protein transport; ER to Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi |
NCBI Summary: | This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95249 |
NCBI GenInfo Identifier: | 12643659 |
NCBI Gene ID: | 9527 |
NCBI Accession: | O95249.1 |
UniProt Secondary Accession: | O95249,O75392, J3KST5, |
UniProt Related Accession: | O95249 |
Molecular Weight: | 250 |
NCBI Full Name: | Golgi SNAP receptor complex member 1 |
NCBI Synonym Full Names: | golgi SNAP receptor complex member 1 |
NCBI Official Symbol: | GOSR1 |
NCBI Official Synonym Symbols: | P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28 |
NCBI Protein Information: | Golgi SNAP receptor complex member 1; cis-golgi SNARE; Golgi SNARE 28 kDa; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; golgi integral membrane protein 2 |
UniProt Protein Name: | Golgi SNAP receptor complex member 1 |
UniProt Synonym Protein Names: | 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28 |
UniProt Gene Name: | GOSR1 |
UniProt Entry Name: | GOSR1_HUMAN |