GLUL Antibody (PACO16424)
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주문- SKU:
- PACO16424
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GLUL Antibody (PACO16424) |
Antibody SKU: | PACO16424 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human GLUL |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16424(GLUL Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Mouse brain tissue, Primary antibody: PACO16424(GLUL Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16424(GLUL Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene. |
Synonyms: | glutamate-ammonia ligase |
UniProt Protein Function: | GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 6.3.1.2; Energy Metabolism - nitrogen; EC 4.1.1.15; Ligase Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:glutamate-ammonia ligase activity; identical protein binding; protein binding Biological Process: amino acid biosynthetic process; cell proliferation; glutamate catabolic process; glutamine biosynthetic process; neurotransmitter uptake Disease: Glutamine Deficiency, Congenital |
NCBI Summary: | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P15104 |
NCBI GenInfo Identifier: | 1169929 |
NCBI Gene ID: | 2752 |
NCBI Accession: | P15104.4 |
UniProt Secondary Accession: | P15104,Q499Y9, Q5T9Z1, Q7Z3W4, Q8IZ17, |
UniProt Related Accession: | P15104 |
Molecular Weight: | 42,064 Da |
NCBI Full Name: | Glutamine synthetase |
NCBI Synonym Full Names: | glutamate-ammonia ligase |
NCBI Official Symbol: | GLUL |
NCBI Official Synonym Symbols: | GS; GLNS; PIG43; PIG59 |
NCBI Protein Information: | glutamine synthetase |
UniProt Protein Name: | Glutamine synthetase |
UniProt Synonym Protein Names: | Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase |
UniProt Gene Name: | GLUL |
UniProt Entry Name: | GLNA_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |