GLS Antibody (PACO19715)
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주문- SKU:
- PACO19715
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GLS Antibody (PACO19715) |
Antibody SKU: | PACO19715 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human GLS |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19715(GLS Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid, base balance in the kidney. Alternate splicing results in multiple transcript variants. |
Synonyms: | glutaminase |
UniProt Protein Function: | glutaminase: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Belongs to the glutaminase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Hydrolase; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Energy Metabolism - nitrogen; EC 3.5.1.2 Chromosomal Location of Human Ortholog: 2q32-q34 Cellular Component: mitochondrion; mitochondrial matrix; cytosol Molecular Function:protein binding; glutaminase activity Biological Process: synaptic transmission; glutamate secretion; suckling behavior; neurotransmitter secretion; glutamine catabolic process; neurological control of breathing; glutamate biosynthetic process; amino acid biosynthetic process; protein homotetramerization |
NCBI Summary: | This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
UniProt Code: | O94925 |
NCBI GenInfo Identifier: | 12643334 |
NCBI Gene ID: | 2744 |
NCBI Accession: | O94925.1 |
UniProt Related Accession: | O94925 |
Molecular Weight: | 65; 73kDa |
NCBI Full Name: | Glutaminase kidney isoform, mitochondrial |
NCBI Synonym Full Names: | glutaminase |
NCBI Official Symbol: | GLS |
NCBI Official Synonym Symbols: | GAC; GAM; KGA; GLS1; AAD20; GDPAG; CASGID; EIEE71 |
NCBI Protein Information: | glutaminase kidney isoform, mitochondrial |
UniProt Protein Name: | Glutaminase kidney isoform, mitochondrial |
UniProt Synonym Protein Names: | K-glutaminase; L-glutamine amidohydrolase |
Protein Family: | Glutaminase |
UniProt Gene Name: | GLS |
UniProt Entry Name: | GLSK_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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