GLP1R Antibody (PACO27029)
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주문- SKU:
- PACO27029
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | GLP1R Antibody (PACO27029) |
Antibody SKU: | PACO27029 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Glucagon-like peptide 1 receptor protein (24-145AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: GLP1R antibody at 12µg/ml Lane 1: Mouse heart tissue Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 54 kDa Observed band size: 54 kDa . | |
Immunofluorescent analysis of 293T cells using PACO27029 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
Synonyms: | Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R), GLP1R |
UniProt Protein Function: | GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2 Chromosomal Location of Human Ortholog: 6p21 Cellular Component: cytosol; integral to membrane; intracellular; plasma membrane Molecular Function:glucagon receptor activity; protein binding; transmembrane receptor activity Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; learning and/or memory; positive regulation of blood pressure; regulation of heart contraction; regulation of insulin secretion; response to stress |
NCBI Summary: | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] |
UniProt Code: | P43220 |
NCBI GenInfo Identifier: | 311033387 |
NCBI Gene ID: | 2740 |
NCBI Accession: | P43220.2 |
UniProt Secondary Accession: | P43220,Q2M229, Q99669, |
UniProt Related Accession: | P43220 |
Molecular Weight: | |
NCBI Full Name: | Glucagon-like peptide 1 receptor |
NCBI Synonym Full Names: | glucagon like peptide 1 receptor |
NCBI Official Symbol: | GLP1R |
NCBI Official Synonym Symbols: | GLP-1; GLP-1R; GLP-1-R |
NCBI Protein Information: | glucagon-like peptide 1 receptor |
UniProt Protein Name: | Glucagon-like peptide 1 receptor |
Protein Family: | Glucagon-like peptide 1 receptor |
UniProt Gene Name: | GLP1R |
UniProt Entry Name: | GLP1R_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |