GK Antibody (PACO46430)
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주문- SKU:
- PACO46430
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GK Antibody (PACO46430) |
Antibody SKU: | PACO46430 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Glycerol kinase protein (346-509AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse spleen tissue. All lanes: GK antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 62, 58, 61, 59 kDa. Observed band size: 62 kDa.. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO46430 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO46430 at dilution of 1:100. |
Background: | Key enzyme in the regulation of glycerol uptake and metabolism. |
Synonyms: | Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase), GK |
UniProt Protein Function: | GLPK: Key enzyme in the regulation of glycerol uptake and metabolism. Defects in GK are the cause of GK deficiency (GKD). This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only. Belongs to the FGGY kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.1.30; Lipid Metabolism - glycerolipid; Mitochondrial; Kinase, other Chromosomal Location of Human Ortholog: Xp21.3 Cellular Component: mitochondrial outer membrane; cytosol; nucleus Molecular Function:glycerol kinase activity; protein binding; ATP binding Biological Process: triacylglycerol metabolic process; glycerol metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; glucose homeostasis; phosphorylation; glycerol-3-phosphate biosynthetic process; glycerol catabolic process Disease: Glycerol Kinase Deficiency |
NCBI Summary: | The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
UniProt Code: | P32189 |
NCBI GenInfo Identifier: | 205830913 |
NCBI Gene ID: | 2710 |
NCBI Accession: | P32189.3 |
UniProt Secondary Accession: | P32189,Q6IQ27, Q8IVR5, Q9UMP0, Q9UMP1, A6NJP5, B2R833 |
UniProt Related Accession: | P32189 |
Molecular Weight: | 58,141 Da |
NCBI Full Name: | Glycerol kinase |
NCBI Synonym Full Names: | glycerol kinase |
NCBI Official Symbol: | GK |
NCBI Official Synonym Symbols: | GK1; GKD |
NCBI Protein Information: | glycerol kinase; ATP:glycerol 3-phosphotransferase; glycerokinase |
UniProt Protein Name: | Glycerol kinase |
UniProt Synonym Protein Names: | ATP:glycerol 3-phosphotransferase |
Protein Family: | Glycerol kinase |
UniProt Gene Name: | GK |
UniProt Entry Name: | GLPK_HUMAN |