GJA8 Antibody (PACO18599)
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주문- SKU:
- PACO18599
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GJA8 Antibody (PACO18599) |
Antibody SKU: | PACO18599 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human GJA8 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18599(GJA8 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18599(GJA8 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. |
Synonyms: | gap junction protein, α 8, 50kDa |
UniProt Protein Function: | GJA8: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. Eye lens. Belongs to the connexin family. Alpha-type (group II) subfamily.Protein type: Membrane protein, integral; Channel, misc.; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q21.1Cellular Component: integral to plasma membraneMolecular Function: channel activityBiological Process: transport; visual perceptionDisease: Cataract 1, Multiple Types; Chromosome 1q21.1 Deletion Syndrome, 1.35-mb |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009] |
UniProt Code: | P48165 |
NCBI GenInfo Identifier: | 13124697 |
NCBI Gene ID: | 2703 |
NCBI Accession: | P48165.3 |
UniProt Secondary Accession: | P48165,Q5VVN9, Q9NP25, A7L5M5 |
UniProt Related Accession: | P48165 |
Molecular Weight: | 48,229 Da |
NCBI Full Name: | Gap junction alpha-8 protein |
NCBI Synonym Full Names: | gap junction protein alpha 8 |
NCBI Official Symbol: | GJA8 |
NCBI Official Synonym Symbols: | CAE; CAE1; CX50; CZP1; MP70; CTRCT1 |
NCBI Protein Information: | gap junction alpha-8 protein |
UniProt Protein Name: | Gap junction alpha-8 protein |
UniProt Synonym Protein Names: | Connexin-50; Cx50; Lens fiber protein MP70 |
Protein Family: | Gap junction alpha-8 protein |
UniProt Gene Name: | GJA8 |
UniProt Entry Name: | CXA8_HUMAN |