GFRA3 Antibody (PACO17987)
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주문- SKU:
- PACO17987
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GFRA3 Antibody (PACO17987) |
Antibody SKU: | PACO17987 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:1000-1:3000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human GFRA3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal kidney tissue, Human brain tissue, Primary antibody: PACO17987(GFRA3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17987(GFRA3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | GDNF family receptor alpha-3 is a protein that in humans is encoded by the GFRA3 gene. The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. |
Synonyms: | GDNF family receptor α 3 |
UniProt Protein Function: | GFRA3: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 5q31.1-q31.3 Cellular Component: extrinsic to membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; external side of plasma membrane Molecular Function:axon guidance receptor activity; receptor binding Biological Process: axon guidance; nervous system development; sympathetic nervous system development; neuron migration; signal transduction; peripheral nervous system development |
NCBI Summary: | The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60609 |
NCBI GenInfo Identifier: | 50403696 |
NCBI Gene ID: | 2676 |
NCBI Accession: | O60609.2 |
UniProt Related Accession: | O60609 |
Molecular Weight: | Observed Molecular Weight: (Observed)44kD.Predicted Molecular Weight: (Calculated)45kDa. |
NCBI Full Name: | GDNF family receptor alpha-3 |
NCBI Synonym Full Names: | GDNF family receptor alpha 3 |
NCBI Official Symbol: | GFRA3 |
NCBI Official Synonym Symbols: | GDNFR3 |
NCBI Protein Information: | GDNF family receptor alpha-3 |
UniProt Protein Name: | GDNF family receptor alpha-3 |
Protein Family: | GDNF family receptor |
UniProt Gene Name: | GFRA3 |
UniProt Entry Name: | GFRA3_HUMAN |
Antibodies |
Anti-GFRA3 Antibody (CAB2955) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |