GFRA2 Antibody (PACO17986)
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주문- SKU:
- PACO17986
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GFRA2 Antibody (PACO17986) |
Antibody SKU: | PACO17986 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human GFRA2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Human liver cancer tissue, Primary antibody: PACO17986(GFRA2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor α 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | GDNF family receptor α 2 |
UniProt Protein Function: | GFRA2: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: extrinsic to membrane; plasma membrane Molecular Function:glial cell line-derived neurotrophic factor receptor activity Biological Process: nervous system development; negative regulation of protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
UniProt Code: | O00451 |
NCBI GenInfo Identifier: | 118582303 |
NCBI Gene ID: | 2675 |
NCBI Accession: | O00451.2 |
UniProt Related Accession: | O00451 |
Molecular Weight: | |
NCBI Full Name: | GDNF family receptor alpha-2 |
NCBI Synonym Full Names: | GDNF family receptor alpha 2 |
NCBI Official Symbol: | GFRA2 |
NCBI Official Synonym Symbols: | NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA |
NCBI Protein Information: | GDNF family receptor alpha-2 |
UniProt Protein Name: | GDNF family receptor alpha-2 |
UniProt Synonym Protein Names: | GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2 |
Protein Family: | GDNF family receptor |
UniProt Gene Name: | GFRA2 |
UniProt Entry Name: | GFRA2_HUMAN |