GDF15 Antibody (PACO22354)
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주문- SKU:
- PACO22354
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GDF15 Antibody (PACO22354) |
Antibody SKU: | PACO22354 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human GDF15. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HepG2 cells and 293 cells, using GDF15 antibody. |
Background: | Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009] |
Synonyms: | GDF-15; growth differentiation factor 15; MIC-1; MIC1; NAG-1 |
UniProt Protein Function: | GDF15: disulfide-linked. Belongs to the TGF-beta family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: extracellular region; extracellular space Molecular Function:transforming growth factor beta receptor binding Biological Process: cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; signal transduction; transforming growth factor beta receptor signaling pathway |
NCBI Summary: | The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q99988 |
NCBI GenInfo Identifier: | 313104195 |
NCBI Gene ID: | 9518 |
NCBI Accession: | Q99988.3 |
UniProt Secondary Accession: | Q99988,O14629, P78360, Q9BWA0, Q9NRT0, |
UniProt Related Accession: | Q99988 |
Molecular Weight: | |
NCBI Full Name: | Growth/differentiation factor 15 |
NCBI Synonym Full Names: | growth differentiation factor 15 |
NCBI Official Symbol: | GDF15 |
NCBI Official Synonym Symbols: | PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15 |
NCBI Protein Information: | growth/differentiation factor 15 |
UniProt Protein Name: | Growth/differentiation factor 15 |
UniProt Synonym Protein Names: | Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor |
Protein Family: | Growth/differentiation factor |
UniProt Gene Name: | GDF15 |
UniProt Entry Name: | GDF15_HUMAN |
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