GCKR Antibody (PACO21844)
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주문- SKU:
- PACO21844
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GCKR Antibody (PACO21844) |
Antibody SKU: | PACO21844 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from internal of human Glucokinase Regulator. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from mouse heart cells and rat heart cells, using Glucokinase Regulator antibody. |
Background: | Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. Hayward B.E., Genomics 49:137-142(1998). |
Synonyms: | Glucokinase regulatory protein; Glucokinase regulator; |
UniProt Protein Function: | GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p23 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:protein binding Biological Process: negative regulation of glucokinase activity; protein import into nucleus, translocation; response to fructose stimulus; urate metabolic process Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5 |
NCBI Summary: | This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14397 |
NCBI GenInfo Identifier: | 327478611 |
NCBI Gene ID: | 2646 |
NCBI Accession: | Q14397.6 |
UniProt Secondary Accession: | Q14397,Q53RY6, Q99522, A1L4C2, B4DPQ2, |
UniProt Related Accession: | Q14397 |
Molecular Weight: | 16,477 Da |
NCBI Full Name: | Glucokinase regulatory protein |
NCBI Synonym Full Names: | glucokinase (hexokinase 4) regulator |
NCBI Official Symbol: | GCKR |
NCBI Official Synonym Symbols: | GKRP; FGQTL5 |
NCBI Protein Information: | glucokinase regulatory protein |
UniProt Protein Name: | Glucokinase regulatory protein |
Protein Family: | Glucokinase regulatory protein |
UniProt Gene Name: | GCKR |
UniProt Entry Name: | GCKR_HUMAN |
Antibodies | ELISA Kits |
Anti-GCKR Antibody (CAB5678) | Human Glucokinase regulatory protein (GCKR) ELISA Kit |
GCKR Antibody (PACO03841) | Glucokinase Regulator Colorimetric Cell-Based ELISA |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |