GCH1 Antibody (PACO18041)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18041
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GCH1 Antibody (PACO18041) |
Antibody SKU: | PACO18041 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:5-1:20 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human GCH1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 12%SDS-PAGE, Lysate: 60 μg, Lane 1-2: Human fetal liver tissue, hela cells, Primary antibody: PACO18041(GCH1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18041(GCH1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid, hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. |
Synonyms: | GTP cyclohydrolase 1 |
NCBI Summary: | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30793 |
NCBI GenInfo Identifier: | 399536 |
NCBI Gene ID: | 2643 |
NCBI Accession: | P30793.1 |
UniProt Related Accession: | P30793 |
Molecular Weight: | 27kDa |
NCBI Full Name: | GTP cyclohydrolase 1 |
NCBI Synonym Full Names: | GTP cyclohydrolase 1 |
NCBI Official Symbol: | GCH1 |
NCBI Official Synonym Symbols: | GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1 |
NCBI Protein Information: | GTP cyclohydrolase 1 |
UniProt Protein Name: | GTP cyclohydrolase 1 |
UniProt Synonym Protein Names: | GTP cyclohydrolase I |
Protein Family: | GTP cyclohydrolase |
UniProt Gene Name: | GCH1 |
UniProt Entry Name: | GCH1_HUMAN |
Antibodies |
Anti-GCH1 Antibody (CAB10616) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |