GBP5 Antibody (PACO16397)
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주문- SKU:
- PACO16397
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GBP5 Antibody (PACO16397) |
Antibody SKU: | PACO16397 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human GBP5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16397(GBP5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16397(GBP5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | GBP5 (guanylate binding protein 5), also known as GBP-TA antigen, is a 586 amino acid, protein that localizes to the cytoplasmic side of the cell membrane. Belonging to the interferon (IFN)-inducible guanylate-binding protein (GBP) family, GBP5 may be involved in the inflammatory response or with cell proliferation and is suggested to have possible cancer-related functions. The gene encoding GBP5 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. |
Synonyms: | guanylate binding protein 5 |
UniProt Protein Function: | GBP5: Stimulates the NLRP3 inflammasome assembly upon bacterial challenge. Belongs to the GBP family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Hydrolase; Vesicle Chromosomal Location of Human Ortholog: 1p22.2 Cellular Component: membrane Molecular Function:identical protein binding; protein binding Biological Process: interleukin-1 beta secretion; positive regulation of innate immune response; protein homotetramerization |
UniProt Code: | Q96PP8 |
NCBI GenInfo Identifier: | 37999757 |
NCBI Gene ID: | 115362 |
NCBI Accession: | Q96PP8.1 |
UniProt Secondary Accession: | Q96PP8,Q86TM5, B2RCE1, |
UniProt Related Accession: | Q96PP8 |
Molecular Weight: | 55,247 Da |
NCBI Full Name: | Guanylate-binding protein 5 |
NCBI Synonym Full Names: | guanylate binding protein 5 |
NCBI Official Symbol: | GBP5 |
NCBI Official Synonym Symbols: | GBP-5 |
NCBI Protein Information: | guanylate-binding protein 5 |
UniProt Protein Name: | Guanylate-binding protein 5 |
UniProt Synonym Protein Names: | GBP-TA antigen; GTP-binding protein 5; GBP-5; Guanine nucleotide-binding protein 5 |
Protein Family: | Guanylate-binding protein |
UniProt Gene Name: | GBP5 |
UniProt Entry Name: | GBP5_HUMAN |