GBA2 Antibody (PACO47146)
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주문- SKU:
- PACO47146
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GBA2 Antibody (PACO47146) |
Antibody SKU: | PACO47146 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Non-lysosomal glucosylceramidase protein (656-867AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO47146 at dilution of 1:100. |
Background: | Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid, 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons. |
Synonyms: | Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2), GBA2, KIAA1605 |
UniProt Protein Function: | GBA2: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo. Belongs to the non-lysosomal glucosylceramidase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.1.45; Endoplasmic reticulum; Hydrolase; Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: integral to membrane; plasma membrane; smooth endoplasmic reticulum Molecular Function:beta-glucosidase activity; glucosylceramidase activity Biological Process: bile acid metabolic process; central nervous system neuron development; glycoside catabolic process; glycosphingolipid metabolic process Disease: Spastic Paraplegia 46, Autosomal Recessive |
NCBI Summary: | This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HCG7 |
NCBI GenInfo Identifier: | 143018392 |
NCBI Gene ID: | 57704 |
NCBI Accession: | Q9HCG7.2 |
UniProt Secondary Accession: | Q9HCG7,Q5TCV6, Q96A51, Q96LY1, Q96SJ2, Q9H2L8, D3DRP2 |
UniProt Related Accession: | Q9HCG7 |
Molecular Weight: | 105kDa |
NCBI Full Name: | Non-lysosomal glucosylceramidase |
NCBI Synonym Full Names: | glucosylceramidase beta 2 |
NCBI Official Symbol: | GBA2 |
NCBI Official Synonym Symbols: | AD035; SPG46; NLGase |
NCBI Protein Information: | non-lysosomal glucosylceramidase |
UniProt Protein Name: | Non-lysosomal glucosylceramidase |
UniProt Synonym Protein Names: | Beta-glucocerebrosidase 2; Beta-glucosidase 2; Glucosylceramidase 2 |
UniProt Gene Name: | GBA2 |