GAP43 Antibody (PACO09410)
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주문- SKU:
- PACO09410
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GAP43 Antibody (PACO09410) |
Antibody SKU: | PACO09410 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human GAP43 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | growth associated protein 43;GAP43;B-50;PP46 ; |
UniProt Protein Function: | GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: 3q13.31 Cellular Component: axon; cell junction; cytoplasm; filopodium membrane; plasma membrane; postsynaptic density Molecular Function:calmodulin binding; phosphatidylserine binding; protein binding Biological Process: axon choice point recognition; cell fate commitment; glial cell differentiation; protein kinase C activation; regulation of filopodium formation; regulation of growth; response to wounding; tissue regeneration |
NCBI Summary: | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P17677 |
NCBI GenInfo Identifier: | 128100 |
NCBI Gene ID: | 2596 |
NCBI Accession: | P17677.1 |
UniProt Secondary Accession: | P17677,A8K0Y4, |
UniProt Related Accession: | P17677 |
Molecular Weight: | |
NCBI Full Name: | Neuromodulin |
NCBI Synonym Full Names: | growth associated protein 43 |
NCBI Official Symbol: | GAP43 |
NCBI Official Synonym Symbols: | B-50; PP46 |
NCBI Protein Information: | neuromodulin |
UniProt Protein Name: | Neuromodulin |
UniProt Synonym Protein Names: | Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46 |
Protein Family: | Neuromodulin |
UniProt Gene Name: | GAP43 |
UniProt Entry Name: | NEUM_HUMAN |