GAD2 Antibody (PACO17927)
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주문- SKU:
- PACO17927
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | GAD2 Antibody (PACO17927) |
Antibody SKU: | PACO17927 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human GAD2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17927(GAD2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17927(GAD2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes one of several forms of glutamic acid, decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid, from L-glutamic acid, A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. |
Synonyms: | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
UniProt Protein Function: | GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family. |
UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - taurine and hypotaurine; Lyase; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate Chromosomal Location of Human Ortholog: 10p11.23 Cellular Component: presynaptic membrane; Golgi membrane; synaptic vesicle membrane; axon; perinuclear region of cytoplasm; plasma membrane; cytosol; cell junction Molecular Function:protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process |
NCBI Summary: | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q05329 |
NCBI GenInfo Identifier: | 1352216 |
NCBI Gene ID: | 2572 |
NCBI Accession: | Q05329.1 |
UniProt Related Accession: | Q05329 |
Molecular Weight: | |
NCBI Full Name: | Glutamate decarboxylase 2 |
NCBI Synonym Full Names: | glutamate decarboxylase 2 |
NCBI Official Symbol: | GAD2 |
NCBI Official Synonym Symbols: | GAD65 |
NCBI Protein Information: | glutamate decarboxylase 2 |
UniProt Protein Name: | Glutamate decarboxylase 2 |
UniProt Synonym Protein Names: | 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform |
Protein Family: | Glutamate decarboxylase |
UniProt Gene Name: | GAD2 |
UniProt Entry Name: | DCE2_HUMAN |
Secondary Antibody |
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