GABPA Antibody (PACO61614)
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주문- SKU:
- PACO61614
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GABPA Antibody (PACO61614) |
Antibody SKU: | PACO61614 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human GA-binding protein α chain protein (268-372AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO61614 diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of Hela cells with PACO61614 at 1:67, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
IHC image of PACO61614 diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. |
Synonyms: | GA-binding protein α chain, GABP subunit alpha, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60, GABPA, E4TF1A |
UniProt Protein Function: | GABPA: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Belongs to the ETS family. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: nuclear chromatin; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity Biological Process: cell differentiation; mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010] |
UniProt Code: | Q06546 |
NCBI GenInfo Identifier: | 729553 |
NCBI Gene ID: | 2551 |
NCBI Accession: | Q06546.1 |
UniProt Secondary Accession: | Q06546,Q12939, |
UniProt Related Accession: | Q06546 |
Molecular Weight: | 51,295 Da |
NCBI Full Name: | GA-binding protein alpha chain |
NCBI Synonym Full Names: | GA binding protein transcription factor alpha subunit |
NCBI Official Symbol: | GABPA |
NCBI Official Synonym Symbols: | NFT2; NRF2; NRF2A; E4TF1A; E4TF1-60; RCH04A07 |
NCBI Protein Information: | GA-binding protein alpha chain |
UniProt Protein Name: | GA-binding protein alpha chain |
UniProt Synonym Protein Names: | Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60 |
Protein Family: | GA-binding protein |
UniProt Gene Name: | GABPA |
UniProt Entry Name: | GABPA_HUMAN |
Antibodies | ELISA Kits |
Anti-GABPA Antibody (CAB12047) | Human GABPA(GA-binding protein alpha chain) ELISA Kit |
Anti-GABPA Antibody (CAB12306) | |
Anti-GABPA Antibody (CAB8419) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |