FZD8 Antibody (PACO19022)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO19022
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | FZD8 Antibody (PACO19022) |
Antibody SKU: | PACO19022 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human FZD8 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19022(FZD8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19022(FZD8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. |
Synonyms: | frizzled family receptor 8 |
UniProt Protein Function: | FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family. |
UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, Fz/Smo family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10p11.21 Cellular Component: Golgi apparatus; integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; receptor binding; PDZ domain binding Biological Process: neuron differentiation; positive regulation of JNK activity; G-protein coupled receptor protein signaling pathway; T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin |
NCBI Summary: | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H461 |
NCBI GenInfo Identifier: | 17433053 |
NCBI Gene ID: | 8325 |
NCBI Accession: | Q9H461.1 |
UniProt Related Accession: | Q9H461 |
Molecular Weight: | 73,300 Da |
NCBI Full Name: | Frizzled-8 |
NCBI Synonym Full Names: | frizzled class receptor 8 |
NCBI Official Symbol: | FZD8 |
NCBI Official Synonym Symbols: | FZ-8; hFZ8 |
NCBI Protein Information: | frizzled-8; frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8 |
UniProt Protein Name: | Frizzled-8 |
Protein Family: | Frizzled |
UniProt Gene Name: | FZD8 |
UniProt Entry Name: | FZD8_HUMAN |
Antibodies | ELISA Kits |
Anti-FZD8 Antibody (CAB18393) | Human Frizzled-8 (FZD8) ELISA Kit |
FZD8 Antibody (PACO05445) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |